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A conjugation of AITC to glutathione in planta might be non-enzymatic or catalysed by GSTs, as indicated by the AITC-induced upregulation of several GST-encoding genes 17,40,41 and similar to what was recently shown for indol-3-ylmethyl-ITC 35

Moreover, the region of DAT (M 1 - V 15 : MSKSKCSVGPMSSVV) responsible for mediating the interaction with D2R is identical between mice and rats, which the same amino acid sequence was used to synthesized TAT-DAT NT

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The implications of this would be formidable

Protocol approach: partial rotator cuff tear Goal: Promote tissue healing, prevent tear progression, avoid surgery if possible Peptide approach: BPC-157: 300 to 500 mcg daily, split doses, local injection near shoulder preferred TB-500: 750 to 1000 mcg twice weekly (loading phase first four weeks), then 500 mcg twice weekly GHK-Cu: 300 to 600 mcg daily from week two onward Duration: Twelve weeks minimum Critical notes: Partial tears require imaging to determine severity and location